James P Simmer Selected Research

Amelogenesis Imperfecta

4/2021	Translational Attenuation by an Intron Retention in the 5' UTR of ENAM Causes Amelogenesis Imperfecta.
1/2021	Odontogenesis-associated phosphoprotein truncation blocks ameloblast transition into maturation in OdaphC41/C41 mice.
1/2019	AMBN mutations causing hypoplastic amelogenesis imperfecta and Ambn knockout-NLS-lacZ knockin mice exhibiting failed amelogenesis and Ambn tissue-specificity.
1/2019	Mutations in RELT cause autosomal recessive amelogenesis imperfecta.
11/2016	Recessive Mutations in ACPT, Encoding Testicular Acid Phosphatase, Cause Hypoplastic Amelogenesis Imperfecta.
10/2016	Mutations in the pH-Sensing G-protein-Coupled Receptor GPR68 Cause Amelogenesis Imperfecta.
7/2015	Critical roles for WDR72 in calcium transport and matrix protein removal during enamel maturation.
2/2015	Hypomaturation amelogenesis imperfecta caused by a novel SLC24A4 mutation.
1/2014	Enamelin is critical for ameloblast integrity and enamel ultrastructure formation.
7/2009	Hypomaturation enamel defects in Klk4 knockout/LacZ knockin mice.

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James P Simmer Research Topics

Disease

16	Amelogenesis Imperfecta 04/2021 - 05/2002
7	Dentinogenesis Imperfecta 12/2022 - 05/2007
5	Dental Pulp Calcification (Denticle) 12/2022 - 01/2011
3	Dentin Dysplasia 01/2016 - 05/2007
2	Osteogenesis Imperfecta (Lobstein Disease) 12/2022 - 01/2012
2	Dental Enamel Hypoplasia 01/2019 - 12/2002
1	Type III Amelogenesis Imperfecta 01/2019
1	Infections 01/2019
1	Hyperphosphatemia 12/2015
1	Familial Hyperphosphatemic Tumoral Calcinosis 12/2015
1	Root Resorption 01/2013
1	Hypercementosis 01/2013
1	Anodontia (Hypodontia) 01/2012
1	Oral Manifestations 01/2012
1	Unerupted Tooth 04/2008
1	Mucopolysaccharidosis IV (Morquio Syndrome) 01/2002

Drug/Important Bio-Agent (IBA)

7	dentin sialophosphoproteinIBA 12/2022 - 12/2008
6	Proteins (Proteins, Gene)FDA Link 01/2019 - 04/2008
3	alpha2 Subunit Collagen Type IIBA 12/2022 - 05/2007
3	tuftelin (enamelin)IBA 01/2014 - 05/2002
2	Amino Acids FDA Link 10/2021 - 01/2019
2	MineralsIBA 01/2013 - 04/2008
1	DNA (Deoxyribonucleic Acid)IBA 12/2022
1	NucleotidesIBA 10/2021
1	5' Untranslated Regions (5' UTR)IBA 04/2021
1	PhosphoproteinsIBA 01/2021
1	RELTIBA 01/2019
1	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA 01/2019
1	azobisisoamylonitrileIBA 01/2019
1	Acid PhosphataseIBA 11/2016
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 10/2016
1	calcium phosphateIBA 12/2015
1	Polypeptide N-acetylgalactosaminyltransferaseIBA 12/2015
1	OligosaccharidesIBA 12/2015
1	Phosphates (Orthophosphate)IBA 12/2015
1	Uridine Diphosphate (UDP)IBA 12/2015
1	potassium-dependent sodium-calcium exchangerIBA 02/2015
1	CarbohydratesIBA 02/2011
1	Proteoglycans (Proteoglycan)IBA 02/2011
1	Peptide Hydrolases (Proteases)FDA Link 01/2011
1	kallikrein 4IBA 07/2009
1	RNA Splice SitesIBA 12/2008
1	Matrix Metalloproteinase 20IBA 12/2002
1	AmelogeninIBA 12/2002
1	Nonsense Codon (Nonsense Mutation)IBA 05/2002
1	AcetylgalactosamineIBA 01/2002
1	Chondroitin Sulfates (Chondroitin Sulfate)IBA 01/2002
1	HydrolasesIBA 01/2002
1	Keratan SulfateIBA 01/2002